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Canadian Journal of Anesthesia 50:528 (2003)
© Canadian Anesthesiologists' Society, 2003

Correspondence

REPLY

Cengiz Karsli, BSC MD FRCPC, Bruno Bissonnette, BSC MD FRCPC and Igor A. Luginbuehl, MD

Toronto, Ontario

We would like to thank Drs. Vavilala and Lam for their interest and comments regarding the effects of propofol on cerebral blood flow velocity (CBFV) in children.1 The suggestion that CBFV changes with age is an accurate one, although the most rapid changes occur outside of the age range of our patient population. From birth to 18 months CBFV increases rapidly, followed by a much slower increase to peak values at around seven years of age.2 As such, the age range of our study patients was in fact chosen in order to minimize age-related effects on CBFV, and we are confident that the analysis reported the variation in CBFV in response to propofol dosing, rather than age-related factors. The coefficient of variation was found to be well within acceptable values, suggesting that variability in CBFV was not likely due to age-related effects.

References

1 Karsli C, Luginbuehl I, Farrar M, Bissonnette B. Propofol decreases cerebral blood flow velocity in anesthetized children. Can J Anesth 2002; 49: 830–4.[Abstract/Free Full Text]

2 Bode H. Methods: recording technique. In: Bode H (Ed.). Paediatric Applications of Transcranial Doppler Sonography. New York: Springer-Verlag; 1988; 21–2, 114.


Related articles in CJA:

Propofol decreases cerebral blood flow velocity in anesthetized children
Monica S. Vavilala and Arthur M. Lam
CJA 2003 50: 527-528. [Full Text]  




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