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Hypothermia and Cerebral Ischemia: Mechanisms and Clinical Applications

Carolina M. Maier, Gary K. Steinberg (Eds). The Haworth Press Inc., 2004. 188 pages. ISBN 0-89603-660-X

London, Ontario

There has been cyclic interest over the last 50 years in the potential cerebral protective benefits of hypothermia. Over the past 15 years the focus has been on the potential benefits of mild (32–34°C) hypothermia. Some of the earliest but rarely quoted experimental studies of mild hypothermia were published in the anesthesia literature in the early 1980’s.

Hypothermia and Cerebral Ischemia: Mechanisms and Clinical Applications is an easily readable book comprising ten chapters. The chapters are authored by international experts, mainly from the U.S.A. but also from Canada, Japan and Germany. The chapters deal with molecular biology, in vivo experiments and clinical trials relating to focal and global ischemia, and head trauma. There is, not surprisingly, much overlap between chapters as there is still much speculation about potential protective mechanisms in the different pathologies. The advantage however of such overlap is that each chapter could be read as an independent review without the need to necessarily read the entire book from cover to cover.

This book is an easily understood "snap shot" of the current state of knowledge. The chapters are more than adequately referenced and current so that the interested reader can use them as springboards for more in-depth reading if desired. This is a topical field that is changing rapidly especially with the ongoing clinical trials and this book presents useful background to understanding and interpreting those results as they come out.

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