CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Blaise, G.
Right arrow Articles by Gao, L.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Blaise, G.
Right arrow Articles by Gao, L.
Canadian Journal of Anesthesia 51:A83 (2004)
© Canadian Anesthesiologists' Society, 2004

Abstracts - Tuesday June 22nd 2004 1030-1230

THE EFFECT OF PREVENTIVE INHALED NITRIC OXIDE ON CEREBRAL INFLAMMATION AFTER CARDIO-PULMONARY BYPASS IN RATS

Gilbert Blaise, MD, Marius D. Gangal, PhD MD and Lan Gao, PhD MD

Laboratoire d’anesthesie, Hospital Notre Dame du CHUM, 1560 rue Sherbrooke East, Montreal QC, H2L 4M1

INTRODUCTION

Despite the improvement in the perfusion techniques, still 42% of the patients suffer from short and long term neuro-cognitive disorders (NCD) after cardio-pulmonary bypass (CPB). Inhaled Nitric Oxide (INO) used as a preventive medication can significantly decrease the pulmonary inflammation (acute lung injury) induced by CPB in pigs and has also extra-pulmonary effects. The objective of our research was to determine if INO can modify NCD induced by general anesthesia (if there are any) and by CPB in rats.

METHODS

We used an animal model developped in our laboratory (CPB in rats) to observe if preventive INO administration is able to modify the neuro-cognitive disorder observed after CPB in rats. We used that model because the neuro-cognitive behavioral evaluation tests are well described in rats and because the costs of the experiments are small.

The animals were randomly divided into 6 groups.


Lot MWMT 1st day CPB 2nd day MWMT 10th day 4% formalin fixation and histo investig CSF
1. Sham Yes No Yes Y Y
2. Sham+INO (box) Yes No Yes Y Y
3. Anesthesia Yes No Yes Y Y
4. Anesthesia and INO Yes No Yes Y Y
5. CPB Yes Yes Yes Y Y
6. CPB + INO Yes Yes Yes Y Y

RESULTS

Preventive INO administration reduce the local inflammatory reaction associated with the reperfusion injuries induced by CPB. INO increase NOx (NO2 and NO3; NO metabolites) level in the CSF.

DISCUSSION

We evaluated the effect of preventive INO on behaviour of rats that underwent to CPB in order to observe if the gas is able to influence the inflammatory response. Our research is at the beginning because NO associated with other gasotransmitters like carbon monoxide and hydrogen sulfide are considered as important neuro-modulators, able to deeply influence the cerebral function.





This Article
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Blaise, G.
Right arrow Articles by Gao, L.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Blaise, G.
Right arrow Articles by Gao, L.

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS