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Canadian Journal of Anesthesia 53:24998 (2006)
© Canadian Anesthesiologists' Society, 2006

Tuesday June 20

24998 - THE EFFECT OF INTRAMUSCULAR MIDAZOLAM ON PAIN RELATED POSTOPERATIVE HERNIORRAPHY

Mahmood Akhlaghi, Assistant Professor, Mohammad Rajaei, Assistant Professor, Hosein Madineh, Assistant Professor and Ramin Habibi

Shahrekord University of Medical Sciences, Shahrekod, CHAHARMAHAL & BAKHTI, Iran

Introduction: The purpose of this study was assessment of intramuscular Midazolam as a premedication on post operative pain and vital signs during a period of eight hours, and to test our hypothesis that the patients are more comfortable and suffering less pain after operation.

Methods: A total of eighty patients aged 15–60 years whom were scheduled for elective inguinal herniorraphy were divided in to two groups of forty each; with ASA class Ι, П; were randomly allocated for this study. Group A "The Test Group" received 0.1mg/kg Midazolam intramuscularly, and Group B "The Control Group" received 0.02cc/kg Saline just after inducing anesthesia with Fentanyl 3μg/kg, Thiopental 5mg/kg as well as Succinylcoline 1.5 mg/kg, and study was done in a randomized double blind fashion. Popular McGill questionnaires were filled for pain severity assessment in four stages (1, 2, 3 and 8 hours after operation), and the patients, vital signs were charted in five stages (preoperative and 1, 2, 3, and 8 hours after operation). The data so obtained was analyzed statistically using Student t test and Chi-Square.

Results: Postoperative pain score average at the first hour in the test group was 2.3 in comparison with 6.6 in the control group (&#961;<0.05). After second and third hours of operation scores of 3.6 and 3.8 in comparison with 6.4 and 6.2 were related to the test and the control groups, respectively (&#961;<0.05). Vital Signs of the patients in the test group were more stable than the control group during the two-hour recovery period (&#961;<0.05). Moreover, the need of intravenous opiate for relieving pain during recover period in the test group was less than the control group.

Discussion: Intramuscular Midazolam appears to cause pain relief after herniorraphy, particularly during recovery period.





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